Advances in pathogenesis of diabetic nephropathy

  • 0.99 MB
  • English
Nova Science Publishers , Hauppauge, N.Y
Etiology, Diabetic nephropathies, Diabetic Nephropa
Statementeditor, Sharma S. Prabhakar
LC ClassificationsRC918.D53 A38 2010
The Physical Object
Paginationp. ;
ID Numbers
Open LibraryOL25176095M
ISBN 139781611221343
LC Control Number2010041333

The past three decades witnessed a plethora of scientific investigations into the pathogenesis of diabetic nephropathy, which attempt to seek the role of several potential cytokines, growth factors, second messengers, vasoactive factors, and candidate genes in leading to structural and functional demise of the kidneys in diabetes.

Establishing more extensive knowledge of pathogenesis is. Diabetic nephropathy is a potentially devastating complication of diabetes, and its incidence has more than doubled in the past decade, 3 largely due to the rising prevalence of obesity and type II diabetes.

4 It has been estimated that patients with diabetes have a twelvefold increased risk of end-stage renal disease ESRD compared to patients. ISBN: OCLC Number: Description: 1 online resource (ix, pages): illustrations.

Contents: Diabetic nephropathy: an overview / Sharma S. Prabhakar --Histopathological aspects of diabetic nephropathy / Irfan Warraich and Ruc Tran --Role of hyperfiltration in the pathogenesis of diabetic nephropathy / Sandra Sabatini and Neil Kurtzman --Experimental.

Forbes, JM, Coughlan, MT & Cooper, MERole of oxidative stress in diabetic nephropathy. in SS Prabhakar (ed.), Advances in Pathogenesis of Diabetic Nephropathy. Nova Cited by: 1. Abdulazim DO () Recent Advances in Management of Diabetic Nephropathy. J Clin Exp Nephrol Vol 2 No 2: Abstract Diabetic nephropathy (DN) is not only the most common cause of end-stage renal disease world-wide but also increases the risk of mortality up to fourteen times compared to normoalbuminuric diabetic patients.

After a long time ofAuthor: Usama Abdel Azim Sharaf El Din, Mona Mansour Salem, Dina Ossama Abdulazim.

Description Advances in pathogenesis of diabetic nephropathy FB2

The advances in genetics and molecular biology will continue to reveal more about the pathogenesis of diabetic nephropathy, but the multifactorial nature of the disease has defied attempts at a general theory that unifies all the known cellular and biochemical : Charbel C.

Khoury, Sheldon Chen, Fuad N. Ziyadeh. item 4 Advances in Pathogenesis of Diabetic Nephropathy, item 8 Advances in Pathogenesis of Diabetic Nephropathy, " They discuss the comparative usefulness of their work in relation to diabetic nephropathy.

This book includes research by internationally renowned experts. Diabetic Nephropathy. Diabetic nephropathy affects approximately % of patients with diabetes mellitus, whether type 1 or type 2. The disease progresses through various clinical stages from hyperfiltration, to microalbuminuria, to macroalbuminuria, to nephrotic proteinuria, to progressive chronic kidney disease that eventually leads to end-stage renal : Charbel C.

Khoury, Sheldon Chen, Fuad N. Ziyadeh. Advances in Pathogenesis of Diabetic Nephropathy (Nephrology Research and Clinical Developments): Medicine & Health Science Books @ Diabetic Nephropathy will be of interest for nephrologists, diabetologists, internists, transplant physicians, public health professionals, basic scientists, geneticists, epidemiologists, pathologists, and molecular and cell biologists working in the field of diabetes and its complications.

Diabetic nephropathy (DN), also known as diabetic kidney disease, is the chronic loss of kidney function occurring in those with diabetes mellitus. Protein loss in the urine due to damage to the glomeruli may become massive, and cause a low serum albumin with resulting generalized body swelling (edema) and result in the nephrotic se, the estimated glomerular filtration rate Specialty: Endocrinology.

Role of Hyperfiltration in the Pathogenesis of Diabetic Nephropathy 3 who would die). In the ’s, patients with diabetes mellitus (as well as the aged) were in the latter group. Diabetic Nephropathy in Humans Renal biopsies of patients with diabetes mellitus reveal both macrovascular as well as microvascular disease.

Pancreatitis Research Advances: Adiponectin: Production, Regulation and Roles in Disease: Advances in Pathogenesis of Diabetic Nephropathy: Diabeto-Angiology: Genetic Endocrinology of the Metabolic Syndrome: Ghrelin: Production, Action Mechanisms and Physiological Effects: Growth Factors in Diabetic Nephropathy pp.

Diabetic Retinopathy: the Need for Predicitive, Preventive and Personalized Approach to Management; Josifova T, Henrich PB 9. The role of inflammatory cytokines in diabetic nephropathy: Potential use as predictive markers for early detection and progression; Elmarakby AE, Baban B, Liu JY, Mozaffari MS   Kawazu S, Tomono S, Shimizu M et al.

The relationship between early diabetic nephropathy and control of plasma glucose in non-insulin-dcpendent diabetes mellitus. The effect of glycemic control on the development and progression of diabetic nephropathy in an 8-year follow-up study. J Diabetes Complications ; – CrossRef Google ScholarCited by: New Tubulocentric Insights for Diabetic Nephropathy: From Pathophysiology to Treatment Chapter (PDF Available) October with Reads How we measure 'reads'.

Title: Insight on the Pathogenesis of Diabetic Nephropathy from the Study of Podocyte and Mesangial Cell Biology VOLUME: 1 ISSUE: 1 Author(s):Gabriella Gruden, Paolo C.

Perin and Giovanni Camussi Affiliation:Department of Internal Medicine, Turin, Italy. Keywords:nephrin, stretch, mesangial cells, podocytes, diabetic nephropathy Abstract: Diabetic nephropathy is characterised by increased Cited by: Get this from a library. Diabetic nephropathy: pathophysiology and clinical aspects.

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[Joris J Roelofs; Liffert Vogt;] -- This book provides an overview of the most up-to-date research on diabetic nephropathy and the current understanding of its pathogenesis, clinical. Diabetic Nephropathy (DN) is the leading cause to end-stage renal disease all over the world.

Unfortunately, no effective treatment is available to stop its progression. So far, many key issues remain unrevealed in relation to its pathogenesis, new forms of therapy, and complication intervention.

This book provides an overview of the current state of clinical and basic research in the field of diabetic nephropathy. It provides a comprehensive and up-to-date synthesis regarding the clinical aspects and pathophysiology of diabetic nephropathy, from a mechanism-based point of view.

Diabetic nephropathy (DN) is the leading cause of kidney failure in the world and has a natural history of progressive albuminuria. Furthermore, diabetic patients with albuminuria have a greatly. Diabetes prevalence is constantly increasing and, nowadays, it affects more than million people worldwide.

Therefore, the prevalence of diabetic nephropathy (DN) has also increased, becoming the main cause of end-stage renal disease (ESRD) in the developed world. DN is characterized by albuminuria, a decline in glomerular filtration rate (GFR), hypertension, mesangial matrix expansion.

Diabetic Nephropathy: Pathophysiology and Clinical Aspects Joris J. Roelofs, Liffert Vogt This book provides an overview of the most up-to-date research on diabetic nephropathy and the current understanding of its pathogenesis, clinical features and socio-economic developments.

Introduction. Pregnancy with pre-existing maternal diabetes significantly increases the risk of excess apoptosis occurs in target tissues of the developing embryos resulting in diabetes-induced birth defects, such as neural tube defects (NTDs) and congenital heart defects (CHDs) Each year, 10% of babies of diabetic mothers are born with a major congenital malformation by: Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy Shinji Kume,1 Takashi Uzu,1 Keiji Isshiki,1 and Daisuke Koya2 1Department of Medicine, Shiga University of Medical Science, Otsu, ShigaJapan 2Division of Endocrinology and Metabolism, Department of Internal Medicine, Kanazawa Medical University, IshikawaJapan Received 30 August ; Accepted 8 Cited by: The role of the Maillard reaction in diabetic complications, for example, has become a major focus of recent research, leading to a better understanding of the importance of hyperglycemia, oxidative stress, and lipid peroxidation in the pathogenesis of complications, including nephropathy, retinopathy, neuropathy, and macrovascular complications.

Author(s): Prabhakar,Sharma S Title(s): Advances in pathogenesis of diabetic nephropathy/ editor, Sharma S. Prabhakar. Country of Publication: United States. The incidence and prevalence of diabetes mellitus have grown significantly throughout the world, due primarily to the increase in type 2 diabetes.

This overall increase in the number of people with diabetes has had a major impact on development of diabetic kidney disease (DKD), one of the most frequent complications of both types of diabetes. DKD is the leading cause of end-stage renal disease Cited by: The following is the summary of a book chapter written by Sandra Sabatini and me in Advances in Pathogensis of Diabetic Nephropathy published by Nova.

The chapter details the current state of our knowledge about globular hyperfiltration as a causal event in the glomerulosclerosis that characterizes diabetic nephropathy. Diabetic kidney disease (DKD) remains the leading cause of end-stage renal disease (ESRD) and is therefore a major burden on the healthcare system.

Patients with DKD are highly susceptible to developing cardiovascular disease, which contributes to increased morbidity and mortality rates.

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While progress has been made to inhibit the acceleration of DKD, current standards of care reduce but do Cited by: 9. New insights into pathogenesis and classification of diseases. New coverage of aging and the kidney, endemic diseases, transplant, lupus-related kidney diseases, Mesoamerican nephropathy, ApolL1-related nephropathies, C3 glomerulopathies, and thrombotic microangiopathies.

Recent results of consensus conferences on vasculitides and renal neoplasia.The aim of this Sadikot\\\\\'s international textbook focuses on diabetes. Worldwise rising prevalence and incidence of diabetes originates from a complex interaction between lifestyle, obesity, and innate susceptibility, driven by both genetic and developmental programming by .The rate of recurrence of primary membranous nephropathy is 55% over 5 years post‐transplantation, 6 and the associated rate of allograft loss is % over 10 years.

1 The pathogenesis involves PLA2R (the phospholipase A2 receptor), the thrombospondin type I domain‐containing 7A protein, and the cationic form of bovine serum by: 2.